Chronic fatigue and depression often look nearly identical on the surface.

Low energy.
Poor concentration.
Sleep disturbances.
Loss of motivation.

Patients frequently ask:
“Is this depression, or am I just exhausted?”

The answer is often both.

Depression doesn’t always present as sadness. In many cases, it presents as physical exhaustion.

Recent reports suggest ketamine may help chronic fatigue. Learn what research shows, who may benefit, and how medical evaluation matters.